Nataridou Kakia was privately taught painting by Evanghelos Ioannides and later by Nikiforos Lytras.
Between 1930 and 1935 she lived in Paris where she studied at the Académie de la Grande Chaumière under André Lhote.
Nataridou worked mainly on portraiture, nude, symbolic and mythological subject matter. Her work combines idealism and symbolism amidst an impressionist mood.
She held many solo exhibitions in Athens and participated in many prestigious group exhibitions such as the 1948, 1957 and 1960 Pan-Hellenic Exhibitions. In 1949 she was awarded the prestigious Arts-Sciences-Lettres medal by the Paris Academy.
Nataridou published the books Ζωγραφική, Μια διατριβή εις την τεχνικήν (Athens 1946) and Γραπτά (Athens 1972)
Her work is found in many public and private collections, notably: The National Gallery, Athens, The Athens Municipal Gallery and The Kalamata Municipal Gallery.